The theoretical and experimental substantiation of the composition of a mouthwash

Aim. To develop the composition and laboratory technology of a therapeutic preventive mouthwash based on plant active ingredient study number its quality indicators. Materials methods. When developing drug, pharmaceutical ingredients (APIs) excipients approved for medical use widely used in practice were selected. The information-search, information-analytical, organoleptic, physicochemical, pharmacotechnological microbiological research methods used. Statistical processing data obtained was performed using Microsoft Excel 2007 spreadsheets. Results discussion. components have been theoretically substantiated. theoretical experimental substantiation original multifaceted action with deodorizing effect halitosis (the liquid extract burdock, pot marigold, fleaworts, horsetail, sage, inula, chicory (45 : 5 15 10 5, respectively) (1 4); thyme lemon essential oil, xylitol, polysorbate-20, glycerin, PEG-40 hydrogenated castor purified water) is given. tests showed need to add antimicrobial preservatives composition. Taking into account requirements safety cost-effectiveness, as well slightly higher activity, potassium sorbate minimum effective concentration 0.1 % chosen promising preservative. Salivary diagnostics revealed general tendency improve physicochemical properties saliva by parameters after applying an sample developed. There Conclusions. drug – effects has